super kiryu powder

In the SK powder “Patent No. 4808822” statement, the findings of measured synthetic amide substrate degradation activity according to the “fibrin and synthetic amide resolution” method of testing the potency of lumbrokinase (earthworm enzymes) are shown as documented in “Clinical Pharmacology and Therapy”, and SK was patented as a new dried earthworm powder method based on this.
Additionally, it is a dried earthworm powder powderized by a safe and secure manufacturing method dealt with in “Patent No. 488601” - the only heat sterilization method that does not cause changes to powder properties.

List of patents

Japanese Patent No. Date acquired in Japan Patent details
2015873 19th February, 1996 Blood-pressure regulation drug (patent application)
2059972 10th June, 1996 Hypolipidemic drug (patent application)
2059973 10th June, 1996 Diabetes drug (patent application)
2090412 18th September, 1996 Method to manufacture former LR powder
3037355 25th February, 2000 Method for manufacturing drugs for thrombosis patients
4699974 11th March, 2011 LR powder manufacturing method (twice the potency of previous LR powder)
4808822 26th August, 2011 SK powder manufacturing method (twice the potency of LR powder and four times that of the older LR powder)
4886017 16th December, 2011 No effect on active ingredients even when powder is heat-treated in our manufacturing method
5243662 12th April, 2013 Tyrosinase inhibitor using dried earthworm powder and its manufacturing method
6002331 9th September, 2016 Catecholamine production accelerant, therapeutic/prophylactic medicine for ailments caused by catecholamine deficiency and therapeutic/prophylactic food composition
6100411 3rd March, 2017 Deodorant manufacturing method and deodorant
Patent owner Kiryu Co., Ltd.
Japan No. 2015873 No. 2059972 No. 2059973 No. 2090412 No. 3037355
Patented date 19th February, 1996 10th June, 1996 10th June, 1996 18th September, 1996 25th February, 2000
United States No. 5024844 No. 5024844 No. 5024844 No. 5128148 No. 5186944
Patented date 18th June, 1991 18th June, 1991 18th June, 1991 7th July, 1992 16th February, 1993
China - - - - -
Patented date - - - - -
Australia No. 619951 No. 619951 No. 619951 No. 619951 No. 619951
Patented date 1st June, 1992 1st June, 1992 1st June, 1992 1st June, 1992 1st June, 1992
South Korea Not filed Not filed Not filed No. 074734 Not filed
Patented date - - - 23rd June, 1994 -
Taiwan - - - - -
Patented date - - - - -
Hong Kong - - - - -
Patented date - - - - -
Canada No. 1322956 No. 1322956 No. 1322956 No. 1322956 -
Patented date 12th October, 1993 12th October, 1993 12th October, 1993 12th October, 1993 -
Russia - - - - -
Patented date - - - - -
Brazil - - - - -
Patented date - - - - -
India - - - - -
Patented date - - - - -
Philippines - - - - No. 27931
Patented date - - - - 17th December, 1993
Israel - - - - -
Patented date - - - - -
EU nations - - - - No. 61798
Germany No. 3827623 No. 3827623 No. 3827623 No. 3827623  
Patented date 1st February, 1996 1st February, 1996 1st February, 1996 1st February, 1996  
France No. 2630008 No. 2630008 No. 2630008 No. 2630008  
Patented date 13th May, 1994 13th May, 1994 13th May, 1994 13th May, 1994  
United Kingdom No. 2208602 No. 2208602 No. 2208602 No. 2208602  
Patented date 5th June, 1991 5th June, 1991 5th June, 1991 5th June, 1991  
Italy No. 1230719 No. 1230719 No. 1230719 No. 1230719  
Patented date 29th October, 1991 29th October, 1991 29th October, 1991 29th October, 1991  
Belgium - - - -  
Denmark - - - -  
Spain - - - -  
Hungary - - - -  
Monaco - - - -  
Netherlands - - - -  
Ireland - - - -  
Patented date - - - - 21th November, 1994

Application No.

Patent owner Well Stone Co.
Japan No. 4699974 No. 4886017 No. 4808822
Patented date 11th March, 2011 16th December, 2011 26th August, 2011
United States No. 8137701 No. 8394417 No. 9511098
Patented date 20th March, 2012 12th May, 2013 6th December, 2016
China No.ZL 2008 1 0088558.4 No.ZL 2010 1 0282979.8 No.ZL 2011 8 0004473.3
Patented date 28th March, 2012 14th November, 2012 3rd July, 2013
Australia No. 2008201345 No. 2010226962 No. 201138109
Patented date 30th August, 2010 22th March, 2012 1st August, 2013
South Korea No. 10-0977113 No. 10-1230763 No. 10-1198192
Patented date 13th August, 2010 31th January, 2013 31th October, 2012
Taiwan No. 330532 No. 400070 No. 376226
Patented date 21st September, 2010 1st July, 2013 11th November, 2012
Hong Kong No. HK1131908 No. HK1155980 No. HK1176882
Patented date 22nd October, 2010 12th June, 2015 30th January, 2014
Canada No. 2627031 2.716.043 2.804.129
Patented date 7th December, 2010 9th October, 2012 20th August, 2013
Russia - No. 2438681 No. 2543318
Patented date - 10th January, 2012 27th February, 2015
Brazil - PI10038310 BR11201300356
Patented date - (Pending) (Pending)
India - 2786/MUM/2010 357/MUMNP/2013
Patented date - (Pending) (Pending)
Philippines 1-2008-000103 1-2010-000319 1-2013-500550
Patented date 31th May, 2013 4th June, 2014 3rd October, 2014
Israel - 208669 227297
Patented date - 31th July, 2013 (Pending)
Indonesia - - W-00201305238
Patented date - - (Pending)
EU nations No. 2105139 No. 2316464 No. 2484369
Germany      
France      
United Kingdom      
Italy      
Netherlands      
Spain   -  
Denmark   -  
Hungary   -  
Monaco   -  
Switzerland   -  
Belgium - -  
Patented date 28th July, 2010 17th September, 2014 14th May, 2014

Three generation comparison

When comparing three generations of powder, we were able to confirm that while SK powder dissolves just like previous powders due to the effect of active ingredients, other ingredients in the protein content (active ingredients + other ingredients) reduced more than previous powders.

Comparison by protein content (active ingredients + other ingredients)

Test comparing SK powder and previous LR powder

Previous LR powder (protein content: 2.0)
SK powder (protein content: 0.9)

Results of test comparing previous LR powder and SK powder

The same results were found in our test comparing the SK powder protein content (0.9) and previous LR powder protein content (2.0).

SK powder manufacturing method research data

  Synthetic substrate Protein content Specific activity (synthetic substrate/protein content)
n mol/ml/min/mg
Old LR powder 403.2 3.0 134.4
Previous LR powder 547.9 2.0 274.0
SK powder 572.4 0.9 636.0

SK demonstrated better results than the old and previous LR powders because other active ingredients in the protein content (active ingredients + other ingredients) reduced.

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